Hydrochloric Acid → 3-Bromo-6-hydroxy-2-methylbenzoic acid

HRID 365955

반응식

HRID 365955 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([C:12]=1[CH3:13])[C:7]([O:9]CC)=[O:8].C(O)C.[OH-].[Na+].Cl>O>[OH:14][C:5]1[CH:4]=[CH:3][C:2]([Br:1])=[C:12]([CH3:13])[C:6]=1[C:7]([OH:9])=[O:8]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14798Sodium HydroxideHCID 23293235HCID 23293235, 화합물

생성물 1

HCID 110534513-Bromo-6-hydroxy-2-methylbenzoic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 1A (20.2 g, 0.078 mol), ethanol (150 ml) and an aqueous sodium hydroxide (12 g, 0.3 mol in 100 ml water) is heated under reflux with stirring for 16 hours. The reaction mixture is cooled to room temperature, diluted with water (600 ml) and acidified with concentrated hydrochloric acid. The precipitate is collected and washed with water yielding 18.45 g (100%) white crystals with a melting point of 163-165° C.

후처리

  1. temperatureunder reflux
  2. customThe precipitate is collected
  3. washwashed with water yielding 18.45 g (100%) white crystals with a melting point of 163-165° C.

출처 및 근거

ORD 기록
ord-1ca1a3967616418894d2d29c8c92c8a9
출처 데이터셋
uspto-grants-2000_10
특허 번호
US06127570

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