Hydrochloric Acid → (6,8-Dichloro-2,4-dihydroxyquinolin-3-yl)(phenyl)methanone

HRID 370469노트

반응식

HRID 370469 반응식
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl-].[Al+3].[Cl-].[Cl-].[N+](C1C=CC=CC=1)([O-])=O.[Cl:23][C:24]1[CH:25]=[C:26]2[C:31](=[C:32]([Cl:34])[CH:33]=1)[NH:30][C:29](=[O:35])[CH:28]=[C:27]2[OH:36].Cl>O>[C:1]([C:28]1[C:29](=[O:35])[NH:30][C:31]2[C:26]([C:27]=1[OH:36])=[CH:25][C:24]([Cl:23])=[CH:33][C:32]=2[Cl:34])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 7412Benzoyl chlorideHCID 7416NitrobenzeneHCID 6451240Aluminum(III) ChlorideHCID 546956806,8-Dichloro-4-hydroxy-2-quinolone

생성물 1

HCID 135687075(6,8-Dichloro-2,4-dihydroxyquinolin-3-yl)(phenyl)methanone수율 65.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Benzoyl chloride (0.93 gram) is added to a mixture of 1.5 grams of anhydrous aluminum chloride and 10 ml of nitrobenzene, the mixture is stirred at room temperature until it becomes uniform, stirred at 105° to 110° C. for eight hours with 1.26 grams of 6,8-dichloro-4-hydroxy-2-quinolone, decomposed with concentrated hydrochloric acid, small amount of water is added thereto, and crystals separated out therefrom are collected by filtration. The crystals are washed with water and then washed with methanol and ether to give 1.2 grams of 3-benzoyl-6,8-dichloro-4-hydroxy-2-quinolone, pale yellow powder, melting point 258° to 259° C.

후처리

  1. additionis added
  2. customcrystals separated
  3. filtrationout therefrom are collected by filtration
  4. washThe crystals are washed with water
  5. washwashed with methanol and ether

출처 및 근거

ORD 기록
ord-e958c3d4a36345979d15fb506dabea24
출처 데이터셋
uspto-grants-1985_07
특허 번호
US04526894

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