Hydrochloric Acid → 1,2,3,4-Tetrahydro-4-methoxy-1-naphthylurea

HRID 372281노트

반응식

HRID 372281 반응식
[OH:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH:12][C:13]([NH2:15])=[O:14])[CH2:4][CH2:3]1.[H-].[Na+].[CH3:18]I.Cl>CN(C)C=O>[CH3:18][O:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]([NH:12][C:13]([NH2:15])=[O:14])[CH2:4][CH2:3]1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 42945181,2,3,4-Tetrahydro-4-hydroxy-1-naphthylurea

생성물 1

HCID 203273121,2,3,4-Tetrahydro-4-methoxy-1-naphthylurea

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A 2.0 g sample of 1,2,3,4-tetrahydro-4-hydroxy-1-naphthylurea (cis/trans) is stirred in 10 ml of dry dimethylformamide and one equivalent of sodium hydride in mineral oil added at 0° C under a nitrogen atmosphere. After the addition is completed, 1.2 equivalents of methyl iodide is added and the reaction mixture stirred overnight. The mixture is carefully poured on ice, neutralized with hydrochloric acid and the title compound collected by filtration. Evaporation of the filtrate to dryness and washing the residue with water affords additional title compound.

후처리

  1. additionAfter the addition
  2. additionThe mixture is carefully poured on ice
  3. filtrationthe title compound collected by filtration
  4. customEvaporation of the filtrate to dryness
  5. washwashing the residue with water

출처 및 근거

ORD 기록
ord-7e3a9aa6ebad4457a285fc2d2149992a
출처 데이터셋
uspto-grants-1978_05
특허 번호
US04089976

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