Sodium Hydroxide → 4-Pentyl-1H-pyrazole

HRID 372942

반응식

HRID 372942 반응식
[CH2:1]([CH:6]([CH:14](OCC)OCC)[CH:7](OCC)OCC)[CH2:2][CH2:3][CH2:4][CH3:5].S(O)(O)(=O)=O.[NH2:26][NH2:27].[OH-].[Na+]>Cl>[CH2:1]([C:6]1[CH:14]=[N:26][NH:27][CH:7]=1)[CH2:2][CH2:3][CH2:4][CH3:5]

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 24842Hydrazine SulfateHCID 124027982-(Diethoxymethyl)-1,1-diethoxyheptane

생성물 1

HCID 232734174-Pentyl-1H-pyrazole

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
90 °C

실험 절차

4-Pentylpyrazole (4-PeP) was prepared by adding 2-Pentyl-1,1,3,3-tetraethoxypropane dropwise with stirring to a solution having a molar equivalent of hydrazine sulfate in 6M HCl at 40°-45° C. The mixture was kept at this temperature for 1 hour and the temperature then raised to 90° C. for 30 minutes. After the mixture cooled, 40% w/w 30 NaOH was added and the mixture thoroughly extracted with ether. Drying the ether solution over MgSO4 afforded 4-PeP. Stock solutions of 4-PeP (3 mM) were prepared by dissolution first in acetonitrile, followed by dilution with water to a final acetonitrile concentration of 8%.

후처리

  1. custom4-Pentylpyrazole (4-PeP) was prepared
  2. customat 40°-45° C
  3. temperatureAfter the mixture cooled
  4. extractionthe mixture thoroughly extracted with ether
  5. dry with materialDrying the ether solution over MgSO4

출처 및 근거

ORD 기록
ord-577ba6c4cd0f4e29a4a01f3d29372537
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05162203

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