Benzyl Chloride → 3-Benzyloxy-2-ethyl-4-pyrone

To a suspension of 2-ethyl-3-hydroxy-4-pyrone (70 g, 0.5 mol) in methanol (650 ml) and sodium hydroxide solution (24 g, 0.6 mol of sodium hydroxide dissolved in 80 ml distilled water) was added benzyl chloride (90 ml, 0.75 mol) with stirring at room temperature. The reaction mixture was refluxed for 24 hours and then cooled. The solvent was removed by rotary evaporation and the residue was extracted into dichloromethane (500 ml). The organic layer was washed with 5% w/v sodium hydroxide solution (3×600 ml) and water (2×600 ml), dried over anhydrous sodium sulphate, filtered and rotary evaporated to give an oil. This oil was crystallized from diethylether in liquid nitrogen and the product recrystallized from diethylether to give the title compound (69 g, 65%) as colourless crystals, m.p. 33°-34° C.

1. temperatureThe reaction mixture was refluxed for 24 hours
2. temperaturecooled
3. customThe solvent was removed by rotary evaporation
4. extractionthe residue was extracted into dichloromethane (500 ml)
5. washThe organic layer was washed with 5% w/v sodium hydroxide solution (3×600 ml) and water (2×600 ml)
6. dry with materialdried over anhydrous sodium sulphate
7. filtrationfiltered
8. customrotary evaporated
9. customto give an oil
10. customThis oil was crystallized from diethylether in liquid nitrogen
11. customthe product recrystallized from diethylether

ORD 기록

ord-9f0d33d0a2f14335a2d242948edd4cec

출처 데이터셋

uspto-grants-1996_01

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US05480894