Cumene → 4'-Iso-propylbenzoin

HRID 375040

반응식

HRID 375040 반응식
O.[C:2]1([C:8]([CH:10]=[O:11])=[O:9])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:12]1([CH:18]([CH3:20])[CH3:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>ClC(Cl)C.[Ti](Cl)(Cl)(Cl)Cl>[CH:18]([C:12]1[CH:17]=[CH:16][C:15]([CH:10]([OH:11])[C:8](=[O:9])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:14][CH:13]=1)([CH3:20])[CH3:19]

참가 물질

5

반응물 2

HCID 7406CumeneHCID 12215922Glyoxal, phenyl-, hydrate

생성물 1

HCID 235130844'-Iso-propylbenzoin

시약·촉매·용매 2

HCID 24193Titanium Tetrachloride촉매HCID 63651,1-Dichloroethane용매

실험 절차

Phenylglyoxal monohydrate (304 mg, 2 mM) and cumene (0.56 ml, 4 mM) were dissolved in dichloroethane (4 ml), titanium tetrachloride (0.33 ml, 3 mM) was added, and reacted at room temperature for 4 hours. Using the same procedure as in Example 1, 4'-iso-propylbenzoin was obtained as crystal (300.6 mg, 59.6% yield).

후처리

  1. customreacted at room temperature for 4 hours

출처 및 근거

ORD 기록
ord-a59f05440ff34bdb954e0a75ad6ad70d
출처 데이터셋
uspto-grants-1996_01
특허 번호
US05484689

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