Carbamate → 2-Methyl-1-naphthol
반응식
ClC(OCC)=O.[OH:7][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][C:9]=1[C:18](O)=O.C(=O)([O-])N.[BH4-].[Na+]>O1CCCC1.O.C(N(CC)CC)C>[CH3:18][C:9]1[CH:10]=[CH:11][C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]=1[OH:7]참가 물질
8
실험 절차
Minami et al (Chem. Pharm. Bull., 27(3), 816-820, 1979) disclose the following reaction scheme: ethyl chloroformate was added, at a temperature of 0°-5° C. and over a period of 1 hour, to a solution of 1-hydroxy-2-naphthoic acid and triethylamine in tetrahydrofuran whereby the correspondence carbamate was produced. The reaction mixture was added to a solution of sodium borohydride in water, with stirring, at a temperature of 5° to 15° C., and over a period of 1 hour. Extraction with ether gave 2-methyl-1-naphthol in a yield of 69.2%.
후처리
- customthe following reaction scheme
- customwas produced
- extractionExtraction with ether
출처 및 근거
- ORD 기록
- ord-bfb307b5515741e097ed404e6b01c0f2
- 출처 데이터셋
- uspto-grants-1995_05
- 특허 번호
- US05420362
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