Hydrochloric Acid → 6-Aminobenzothiazole

반응식

Cl[Sn]Cl.Cl.[N+:5]([C:8]1[CH:16]=[CH:15][C:11]2[N:12]=[CH:13][S:14][C:10]=2[CH:9]=1)([O-])=O.[OH-].[Na+]>>[NH2:5][C:8]1[CH:16]=[CH:15][C:11]2[N:12]=[CH:13][S:14][C:10]=2[CH:9]=1

참가 물질

반응물 4

HCID 313Hydrochloric Acid

HCID 14798Sodium Hydroxide

HCID 24479Stannous Chloride

HCID 762566-Nitrobenzothiazole

생성물 1

HCID 682886-Aminobenzothiazole수율 96%

반응 조건

온도: 25 °C

실험 절차

To a solution of SnCl2 (1.5 g, 1.9 mmol) and 5 mL of con.HCl was added 6-nitrobenzothiazole (0.60 g, 3.4 mmol) in a portion and resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was basified with aqueous NaOH and extracted with EtOAc. Combined organic layers were dried over Na2SO4 and concentrated in vacuo, yielding an oil (0.47 g, 3.2 mmol, 96%) which was identified as the amine (>95%) and subjected to the following reaction without further purification.