홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Ethanol → 3-[4-(4-Chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride

HRID 3811
노트
인쇄 미리보기

반응식

HRID 3811 반응식
NC(N)=[S:3].[Cl:5][C:6]1[CH:24]=[CH:23][C:9]([CH2:10][N:11]2[CH2:16][CH:15]([CH3:17])[N:14]([CH2:18][CH2:19][CH2:20]Cl)[CH2:13][CH:12]2[CH3:22])=[CH:8][CH:7]=1.C(O)C.[OH-].[Na+]>O>[ClH:5].[ClH:5].[Cl:5][C:6]1[CH:24]=[CH:23][C:9]([CH2:10][N:11]2[CH:12]([CH3:22])[CH2:13][N:14]([CH2:18][CH2:19][CH2:20][SH:3])[CH:15]([CH3:17])[CH2:16]2)=[CH:8][CH:7]=1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 702EthanolHCID 14798Sodium HydroxideHCID 2723790ThioureaHCID 201531901-(4-Chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine

생성물 1

HCID 201531723-[4-(4-Chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride수율 249.9%

시약·촉매·용매 1

HCID 962
Water
용매

실험 절차

The procedure described in Example 1(b) was followed, using 12.7 g of thiourea and 26.0 g of 1-(4-chlorobenzyl)-2,5-dimethyl-4-(3-chloropropyl)piperazine in 250 ml of reagent ethanol. The hydrolysis was effected with 10.0 g of sodium hydroxide in 50 ml of water. Work-up, as described above, gave 26.5 g (83% of theory) of 3-[4-(4-chlorobenzyl)-2,5-dimethylpiperazin-1-yl]propanethiol dihydrochloride as a white crystalline solid, M.p. 168°-171° C.

출처 및 근거

ORD 기록
ord-ac25165bc3e44b80977c05d9becefbc7
출처 데이터셋
uspto-grants-1988_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04722926

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차출처 및 근거반응 노트