Hydrogen Bromide → HCID 68820841, 화합물

HRID 41499

반응식

HRID 41499 반응식
CS(C)=O.[BrH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]>CC(O)C>[BrH:5].[CH3:6][C:7]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:37][CH3:38])=[C:32]([O:35][CH3:36])[CH:33]=4)[N:28]=[C:27]([NH:39][CH3:40])[N:26]=3)[CH:20]=2)=[O:17])[CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10]

참가 물질

5

반응물 3

HCID 260Hydrogen BromideHCID 679Dimethyl SulfoxideHCID 66646296methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid

생성물 1

HCID 68820841HCID 68820841, 화합물

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

Dimethyl sulfoxide (1 mL) and hydrobromic acid (40 μL) were added to methyl N-[3-(6,7-dimethoxy-2-methylaminoquinazolin-4-yl)phenyl]terephthalamic acid (100.90 mg). 2-Propanol (5 mL) was added to the mixture while heating the mixture, and the mixture was cooled to room temperature to be solidified. The solid was collected by filtration to yield the titled compound (108.92 mg).

후처리

  1. temperaturewhile heating the mixture
  2. filtrationThe solid was collected by filtration

출처 및 근거

ORD 기록
ord-c3aa049b7aa9465693f6054ed6d6261f
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530654B2

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