Phosphorus oxybromide → 2-Bromo-5-nitro-3-phenylpyridine

HRID 41981

반응식

HRID 41981 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:7](O)=[N:8][CH:9]=1)([O-:3])=[O:2].P(Br)(Br)([Br:19])=O.P(Br)(Br)Br>O>[Br:19][C:7]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:5][C:4]([N+:1]([O-:3])=[O:2])=[CH:9][N:8]=1

참가 물질

5

반응물 3

HCID 24613Phosphorus oxybromideHCID 24614Phosphorus tribromideHCID 1785268355-Nitro-3-phenylpyridin-2-ol

생성물 1

HCID 866572532-Bromo-5-nitro-3-phenylpyridine수율 62%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

A mixture of 5-nitro-3-phenylpyridin-2-ol (4.63 mmol, 1 g), POBr3 (4.74 mmol, 0.45 ml) and PBr3 (4.71 mmol, 1.4 g) was heated at 120° C. for 3.5 hours. The crude mixture was poured into a mixture of ice and water and extracted with DCM. The organic phase was dried and evaporated affording 0.8 g (yield 62%) of the expected product.

후처리

  1. extractionextracted with DCM
  2. customThe organic phase was dried
  3. customevaporated

출처 및 근거

ORD 기록
ord-da2a4b647a9443d59f2c8767e3498714
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536165B2

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