Sodium Hydroxide → 6-[(Pyridin-2-yl)methoxy]pyridin-3-amine

HRID 427722노트

반응식

HRID 427722 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[N:8][CH:9]=1)([O-])=O.[Sn](Cl)Cl.[OH-].[Na+]>C(O)C.Cl.O>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)=[N:8][CH:9]=1

참가 물질

7

반응물 3

HCID 14798Sodium HydroxideHCID 24479Stannous ChlorideHCID 183577252-(Pyridin-2-ylmethoxy)-5-nitropyridine

생성물 1

HCID 154477886-[(Pyridin-2-yl)methoxy]pyridin-3-amine수율 78%

시약·촉매·용매 3

HCID 313Hydrochloric Acid용매HCID 702Ethanol용매HCID 962Water용매

반응 조건

온도
50 °C

실험 절차

5-Nitro-2-(pyridin-2-ylmethyloxy)pyridine (D1, 2.0 g, 0.0087 mole) in ethanol (70 ml) was treated with tin (II) chloride (8.3 g, 0.044 mole) in conc. HCl (15 ml). The mixture was heated to 50° C. for 0.5 hour. After cooling to room temperature, the mixture was diluted with water, basified with 10% aqueous sodium hydroxide solution, extracted into ethyl acetate, dried (Na2SO4) and evaporated in vacuo to afford the title compound (1.36 g, 78%) as a brown oil.

후처리

  1. temperatureAfter cooling to room temperature
  2. extractionextracted into ethyl acetate
  3. dry with materialdried (Na2SO4)
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-19bdabcaa6ba44608332a5b83fb7d5f1
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06313145B1

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