Styrene → trans-Stilbene

HRID 429608

반응식

HRID 429608 반응식
C([O-])(=O)C.[Na+].Cl[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH2:13]=[CH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>[P+](C1C=CC=CC=1)(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Cl-].CN(C=O)C>[C:7]1(/[CH:13]=[CH:14]/[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:7]1(/[CH:13]=[CH:14]\[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[C:7]1([C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH2:13])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

8

반응물 3

HCID 7501StyreneHCID 7964ChlorobenzeneHCID 517045Sodium Acetate

생성물 3

HCID 107401,1-Diphenylethylene수율 14.4%HCID 638088trans-Stilbene수율 84.9%HCID 5356785cis-Stilbene수율 0.7%

시약·촉매·용매 2

HCID 164911Tetraphenylphosphonium Chloride촉매HCID 6228Dimethylformamide용매

실험 절차

A reaction is performed as described in Example 1, except that 10.3 mg (0.04 mmol) of (CH3CN)2PdCl2, 59.7 mg (0.16 mmol) of Ph4PCl, 157.6 mg (1.92 mmol) of anhydrous sodium acetate, 107.1 mg (0.95 mmol) of chlorobenzene and 136.2 mg (1.31 mmol) of styrene in 1 ml of DMF are reacted. Stirring is performed at 150° C. for 8 hours. With 95.6% conversion of Cl-benzene, a 70.4% yield of Heck products (84.9% trans-stilbene, 0.7% cis-stilbene, and 14.4% 1,1-diphenylethene) is obtained.

후처리

  1. customare reacted

출처 및 근거

ORD 기록
ord-a2489af76f8f455489a19371317c7868
출처 데이터셋
uspto-grants-2001_11
특허 번호
US06316675B1

연결된 노트

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