Diethyl Sulfate → N-[4-(diethylamino)-2-methylphenyl]acetamide

HRID 436551

반응식

HRID 436551 반응식
[NH:1]([C:5]1[CH:13]=[CH:12][C:8]([NH:9][CH2:10][CH3:11])=[CH:7][C:6]=1[CH3:14])[C:2]([CH3:4])=[O:3].S(OCC)(O[CH2:19][CH3:20])(=O)=O.[OH-].[Na+]>O>[NH:1]([C:5]1[CH:13]=[CH:12][C:8]([N:9]([CH2:19][CH3:20])[CH2:10][CH3:11])=[CH:7][C:6]=1[CH3:14])[C:2]([CH3:4])=[O:3]

참가 물질

5

반응물 3

HCID 6163Diethyl SulfateHCID 14798Sodium HydroxideHCID 214528314-Acetamino-3-methyl-N-ethylaniline

생성물 1

HCID 222177N-[4-(diethylamino)-2-methylphenyl]acetamide수율 64.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

19.1g (0.1 mole) of 4-acetamino-3-methyl-N-ethylaniline obtained in Example 1, Part C, and 100g of water were mixed, and, after 12.5g of diethyl sulfate were added dropwise thereto while stirring, the entire reaction system was stirred overnight at room temperature. Next, the reaction mixture was neutralized with sodium hydroxide and the crystals separated were recrystallized from methanol to obtain 11.5g of white crystals of 4-acetamino-3-methyl-(N,N-diethyl)aniline.

후처리

  1. stirringthe entire reaction system was stirred overnight at room temperature
  2. customthe crystals separated
  3. customwere recrystallized from methanol

출처 및 근거

ORD 기록
ord-07f5cee7c9e849128dbff41ea39d7b24
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04009205

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