Pyruvic Acid → HCID 22405542, 화합물

HRID 441211

반응식

HRID 441211 반응식
[NH2:1][C:2]1[C:3](=[O:28])[N:4]([CH2:14][C:15]([NH:17][CH:18]([CH:25]([CH3:27])[CH3:26])[C:19](=[O:24])[C:20]([F:23])([F:22])[F:21])=[O:16])[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:6][CH:7]=1.ON1C2C=CC=CC=2N=N1.[C:39](O)(=[O:43])[C:40]([CH3:42])=[O:41].COC1C=CC(CC(O)=O)=CC=1>CN(C)C1C=CN=CC=1.ClCCl.O1CCCC1>[O:28]=[C:3]1[C:2]([NH:1][C:39](=[O:43])[C:40]([CH3:42])=[O:41])=[CH:7][CH:6]=[C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:4]1[CH2:14][C:15]([NH:17][CH:18]([CH:25]([CH3:26])[CH3:27])[C:19](=[O:24])[C:20]([F:22])([F:23])[F:21])=[O:16]

참가 물질

8

반응물 4

HCID 1060Pyruvic AcidHCID 76904-Methoxyphenylacetic AcidHCID 757711-HydroxybenzotriazoleHCID 102500732-(3-Amino-2-oxo-6-phenyl-2H-pyridin-1-yl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl)-acetamide

생성물 1

HCID 22405542HCID 22405542, 화합물

시약·촉매·용매 3

HCID 142844-(Dimethylamino)pyridine촉매HCID 6344Dichloromethane용매2회HCID 8028Tetrahydrofuran용매

실험 절차

2-(3-Amino-2-oxo-6-phenyl-1,2-dihydro-1-pyridyl)-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide was subjected to procedure similar to Acylation Method B, but substituting: dichloromethane for tetrahydrofuran, 4-dimethylaminopyridine for 1-hydroxybenzotriazole, and pyruvic acid for 4-methoxyphenyl acetic acid. After 72 h, dichloromethane was added and the mixture was washed (water, brine), dried (magnesium sulfate) and evaporated. Chromatography, eluting with dichloromethane:methanol (gradient, 99.5:0.5, 99:1), gave the title compound as a pale yellow solid; TLC: Rf =0.44, dichloromethane:methanol (98:2); MS: m/z=466(M+1).

후처리

  1. washthe mixture was washed (water, brine)
  2. dry with materialdried (magnesium sulfate)
  3. customevaporated
  4. washChromatography, eluting with dichloromethane

출처 및 근거

ORD 기록
ord-6ed4f2edb3374584b7c18a037ad329ed
출처 데이터셋
uspto-grants-1996_05
특허 번호
US05521179

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