Trichloroacetyl chloride → 2-(Trichloroacetyl)pyrrole

HRID 44255

반응식

HRID 44255 반응식
[Cl:1][C:2]([Cl:7])([Cl:6])[C:3](Cl)=[O:4].[NH:8]1[CH:12]=[CH:11][CH:10]=[CH:9]1.C(=O)([O-])[O-].[K+].[K+]>C(OCC)C.O>[Cl:1][C:2]([Cl:7])([Cl:6])[C:3]([C:9]1[NH:8][CH:12]=[CH:11][CH:10]=1)=[O:4]

참가 물질

6

반응물 3

HCID 6420Trichloroacetyl chlorideHCID 8027PyrroleHCID 11430Potassium Carbonate

생성물 1

HCID 3214872-(Trichloroacetyl)pyrrole

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매2회

실험 절차

To a solution of trichloroacetyl chloride (160.7 mmoles) in ethyl ether (26 ml) there is added, dropwise over a period of 3 hours, a solution of pyrrole (149 mmoles) in ethyl ether (83 ml). After stirring for a further hour, a solution of potassium carbonate (94 mmoles) in water (39 ml) is added dropwise. The phases are separated and the organic phase is dried over sodium sulphate and filtered. Active carbon is added to this organic phase. After stirring for 5 minutes, the organic phase is filtered and evaporated to dryness to yield the title product.

후처리

  1. customThe phases are separated
  2. dry with materialthe organic phase is dried over sodium sulphate
  3. filtrationfiltered
  4. additionActive carbon is added to this organic phase
  5. stirringAfter stirring for 5 minutes
  6. filtrationthe organic phase is filtered
  7. customevaporated to dryness

출처 및 근거

ORD 기록
ord-c606efcc6d174fd5af17b1eca1f8b113
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541412B2

연결된 노트

불러오는 중…