Hydrochloric Acid → 4'-Nonanoyloxybiphenyl-4-carboxylic acid

HRID 442594

반응식

HRID 442594 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:17](Cl)(=[O:26])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25].CN(C1C=CC=CN=1)C.Cl>ClCCl.C(N(CC)CC)C>[C:17]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1)(=[O:26])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 218852-DimethylaminopyridineHCID 69819Nonanoyl chlorideHCID 3015564'-Hydroxy-4-biphenylcarboxylic acid

생성물 1

HCID 136684514'-Nonanoyloxybiphenyl-4-carboxylic acid수율 86.3%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8471Triethylamine용매

실험 절차

4'-Hydroxybiphenyl-4-carboxylic acid (3.5 g) and triethylamine (2.4 g) were dissolved in dichloromethane (30 ml). Nonanoyl chloride (4.3 g) and dimethylaminopyridine (0.2 g) were added to the solution, and the mixture was stirred at room temperature for about 20 hours. Dilute hydrochloric acid was added thereto, and the organic layer was separated in a separating funnel. The solvent was removed by evaportaion, and the residue was dried after washing with n-hexane to give the titled compound (5 g).

후처리

  1. customthe organic layer was separated in a separating funnel
  2. customThe solvent was removed by evaportaion
  3. customthe residue was dried
  4. washafter washing with n-hexane

출처 및 근거

ORD 기록
ord-0fbb1e06db2441929e7b81c2113f4d94
출처 데이터셋
uspto-grants-1999_04
특허 번호
US05891359

연결된 노트

불러오는 중…