Hydrochloric Acid → Acetic acid, 2-((2-chlorobenzoyl)amino)-

HRID 44438노트

반응식

HRID 44438 반응식
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[OH-].[Na+].[Cl:8][C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11](Cl)=[O:12].Cl>O>[Cl:8][C:9]1[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([NH:1][CH2:2][C:3]([OH:5])=[O:4])=[O:12]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 750GlycineHCID 14798Sodium HydroxideHCID 691102-Chlorobenzoyl chloride

생성물 1

HCID 177756Acetic acid, 2-((2-chlorobenzoyl)amino)-수율 80%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a stirred solution of glycine (100 mmol) and NaOH (100 mmol) in water (300 ml), at 5° C., o-chloro-benzoyl chloride (110 mmol) was added in small portions. The reaction mixture was stirred for 30 minutes at room temperature, then cooled again and acidified to pH=2 by addition of 6 M HCl. Extraction of the aqueous solution was performed with EtOAc. Then, the combined organic layers were dried over MgSO4 and the solvent was removed by reduced pressure. The residue was triturated in boiling chloroform, and the product was collected by filtration in 80% yield.

후처리

  1. temperaturecooled again
  2. extractionExtraction of the aqueous solution
  3. dry with materialThen, the combined organic layers were dried over MgSO4
  4. customthe solvent was removed by reduced pressure
  5. customThe residue was triturated
  6. filtrationthe product was collected by filtration in 80% yield

출처 및 근거

ORD 기록
ord-4a9fdad254f04dc1b4dd32db485b3fe6
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541428B2

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