Hydrochloric Acid → 1-Bromo-2-(2,2-dimethoxypropyl)benzene
반응식
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9](=[O:11])[CH3:10].[CH:12](OC)(OC)[O:13]C.Cl.O1CCOC[CH2:21]1.CCN(C(C)C)C(C)C>CO>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:13][CH3:12])([O:11][CH3:21])[CH3:10]참가 물질
7
실험 절차
2-Bromophenylacetone (4.45000 g, 21 mmol) was dissolved in 10 mL MeOH and trimethyl orthoformate (11 mL, 104 mmol) and hydrogen chloride, 4.0M solution in 1,4-dioxane (5.2 mL, 21 mmol) were added. The mixture was stirred for 1 h and neutralized carefully with DIEA (pH 7). The mixture was evaporated and filtered through a plug of silica providing 1-bromo-2-(2,2-dimethoxypropyl)benzene as a colorless liquid.
후처리
- customThe mixture was evaporated
- filtrationfiltered through a plug of silica
출처 및 근거
- ORD 기록
- ord-23781c5df85b49ce81363cf3768034e1
- 출처 데이터셋
- uspto-grants-2013_07
- 특허 번호
- US08476297B2
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