Isoquinoline → isoquinolin-N-oxide

HRID 44819

반응식

HRID 44819 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.C1C=C(Cl)C=C(C(OO)=[O:19])C=1>C(Cl)(Cl)Cl>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N+:2]=1[O-:19]

참가 물질

4

반응물 2

HCID 8405IsoquinolineHCID 70297m-Chloroperbenzoic acid

생성물 1

HCID 290378isoquinolin-N-oxide

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a stirred solution of isoquinoline (1-Im-9, 5 g, 1.0 eq) in 50 mL of CHCl3, mCPBA (2.0 eq) was added. The mixture was stirred at rt for 1 h. The reaction was washed with 5% aqueous Na2SO3 and aqueous Na2CO3, then concentrated and the residue was purified by silica column chromatography to give isoquinoline 2-oxide (2-Im-9).

후처리

  1. washThe reaction was washed with 5% aqueous Na2SO3 and aqueous Na2CO3
  2. concentrationconcentrated
  3. customthe residue was purified by silica column chromatography

출처 및 근거

ORD 기록
ord-e6b18eeb6a8c4466b0200d7320f148d3
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541418B2

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