Methyl iodide → 4-Bromo-2-(methoxymethyl)thiophene

HRID 456528

반응식

HRID 456528 반응식
[H-].[Na+].[CH3:3]I.[Br:5][C:6]1[CH:7]=[C:8]([CH2:11][OH:12])[S:9][CH:10]=1>O1CCCC1>[Br:5][C:6]1[CH:7]=[C:8]([CH2:11][O:12][CH3:3])[S:9][CH:10]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 2795484(4-Bromo-2-thienyl)methanol

생성물 1

HCID 150183124-Bromo-2-(methoxymethyl)thiophene

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Add sodium hydride (737 mg, 29.23 mmol, 1.10 equivalents, 95%) to a solution containing methyl iodide (1.65 mL, 26.57 mmol, 1.00 equivalents) and (4-bromo-thiophen-2-yl)-methanol (5.13 g, 26.57 mmol, 1.00 equivalents) in tetrahydrofuran (dry, 25 mL). Stir the resulting mixture at room temperature overnight and evaporate. Partition the residue between water (100 mL) and dichloromethane (100 mL). Extract the aqueous layer with dichloromethane (100 mL), combine the organic layers, dry over magnesium sulfate, filter and evaporate to yield the desired product as a yellow oil.

후처리

  1. customevaporate
  2. customPartition the residue between water (100 mL) and dichloromethane (100 mL)
  3. extractionExtract the aqueous layer with dichloromethane (100 mL)
  4. dry with materialdry over magnesium sulfate
  5. filtrationfilter
  6. customevaporate

출처 및 근거

ORD 기록
ord-ac324890fddb41bea7ead4ba5dc52f23
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186724B2

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