Phenol → 4,4,4'4'-Tetra(3-isopropyl-4-hydroxyphenyl)bicyclohexene

HRID 460500

반응식

HRID 460500 반응식
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([CH3:3])[CH3:2].[C:11]1([OH:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[C:18]1(=[O:30])[CH2:23][CH2:22][CH:21]([CH:24]2[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]2)[CH2:20][CH2:19]1>CO>[CH:1]([C:4]1[CH:9]=[C:8]([C:24]2([C:21]3[CH:22]=[CH:23][C:18]([OH:30])=[C:19]([CH:7]([CH3:8])[CH3:6])[CH:20]=3)[CH2:29][CH2:28][C:27]([C:27]3[CH2:28][CH2:29][C:24]([C:21]4[CH:22]=[CH:23][C:18]([OH:30])=[C:19]([CH:4]([CH3:9])[CH3:5])[CH:20]=4)([C:14]4[CH:15]=[CH:16][C:11]([OH:17])=[C:12]([CH:1]([CH3:3])[CH3:2])[CH:13]=4)[CH2:25][CH:26]=3)=[CH:26][CH2:25]2)[CH:7]=[CH:6][C:5]=1[OH:10])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 996Phenol2회HCID 69432-Isopropylphenol2회HCID 41690(1,1'-Bicyclohexyl)-4-one2회

생성물 1

HCID 184461464,4,4'4'-Tetra(3-isopropyl-4-hydroxyphenyl)bicyclohexene수율 232.7%

시약·촉매·용매 1

HCID 887Methanol용매4회

실험 절차

The same method as specified in Reference Example 1 was used, except that 236.8 g of 0-isopropyl phenol and 23.7 g of methanol were used instead of 209.4 g of phenol and 18.9 g of methanol, and that a solution made of 39.0 g of 4,4′-bicyclohexanon and 39.0 g of 0-isopropyl phenol dissolved in 15.8 g of methanol was used instead of a solution made of 24.2 g of 4,4′-bicyclohexanon and 24.2 g of phenol dissolved in 24.2 g of methanol, to achieve reaction, neutralization, crystallization and filtering to obtain 175.9 g of 4,4,4′4′-tetra(3-isopropyl-4-hydroxyphenyl)bicyclohexene as white solid (still wet with the solution).

후처리

  1. customreaction, neutralization, crystallization
  2. filtrationfiltering

출처 및 근거

ORD 기록
ord-615c9b1d0f7a4ec4b34e754003081310
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07196232B2

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