Acetoacetanilide → Isoquinoline

HRID 462488

반응식

CC(CC(N[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O)=O.[C:14](#[N:18])[CH2:15][C:16]#N>>[CH:14]1[C:15]2[C:8](=[CH:9][CH:10]=[CH:11][CH:16]=2)[CH:13]=[CH:12][N:18]=1

참가 물질

반응물 2

HCID 7592Acetoacetanilide

HCID 8010Malononitrile

생성물 1

HCID 8405Isoquinoline수율 85%

실험 절차

The procedure of Reference Example 5 was repeated except that 0.04 mole of acetoacetic anilide (Reference Example 8) or 0.04 mole of malononitrile (Reference Example 9) was employed instead of acetylacetone to give a corresponding isoquinoline derivative with yield of 85%, 65%, respectively. The structures of the obtained isoquinoline derivatives were identified by means of elementary analysis, IR spectrum and 1H-NMR spectrum.

출처 및 근거

ORD 기록: ord-72762389c1184c49931862144a7299b7
출처 데이터셋: uspto-grants-1985_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04515915

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