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2,4-Difluoroaniline → HCID 45280642, 화합물

HRID 473472
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HRID 473472 반응식
Cl[C:2]1[CH:3]=[CH:4][C:5]2[C:11](=[O:12])[C:10]3[CH:13]=[CH:14][CH:15]=[C:16]([O:17][CH2:18][C@H:19]4[CH2:23][O:22][C:21]([CH3:25])([CH3:24])[O:20]4)[C:9]=3[CH2:8][CH2:7][C:6]=2[CH:26]=1.[F:27][C:28]1[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:29]=1[NH2:30].P.O(C(C)(C)C)[Na]>C1(C)C=CC=CC=1.C(O)(C)(C)C.CC([O-])=O.CC([O-])=O.[Pd+2]>[F:27][C:28]1[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:29]=1[NH:30][C:2]1[CH:3]=[CH:4][C:5]2[C:11](=[O:12])[C:10]3[CH:13]=[CH:14][CH:15]=[C:16]([O:17][CH2:18][C@H:19]4[CH2:23][O:22][C:21]([CH3:25])([CH3:24])[O:20]4)[C:9]=3[CH2:8][CH2:7][C:6]=2[CH:26]=1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

8

반응물 4

HCID 97092,4-DifluoroanilineHCID 24404PhosphineHCID 67361716HCID 67361716, 화합물HCID 178418730sodium 2-methylpropan-2-olate

생성물 1

HCID 45280642HCID 45280642, 화합물수율 37%

시약·촉매·용매 3

HCID 167845palladium(II) acetate
촉매
HCID 1140Toluene용매
HCID 6386tert-Butanol용매

실험 절차

For the synthesis of the title compound, 0.50 g (0.0013 mol) of (S)-8-chloro-1-(2,2-dimethyl-[1,3]dioxolan-4-ylmethoxy)-10,11-dihydrodibenzo[a,d]cyclohepten-5-one, 0.17 g (0.0013 mol) of 2,4-difluoroaniline, 2 spatula tips of Pd(OAc)2, 0.14 g of phosphine ligand and 0.70 g (0.0073 mol) of NaOtert-Bu in 10 ml of toluene and 2 ml of tert-BuOH are reacted by method O.

출처 및 근거

ORD 기록
ord-2500964f4a7e4c3989375415b548ffb6
출처 데이터셋
uspto-grants-2014_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08633312B2

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