Benzyl Chloride → 5-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine

HRID 477732

반응식

HRID 477732 반응식
[NH2:1][C:2]1[N:6]=[C:5]([SH:7])[NH:4][N:3]=1.[OH-].[Na+].[CH2:10](Cl)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[NH2:1][C:2]1[NH:3][N:4]=[C:5]([S:7][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:6]=1

참가 물질

5

반응물 3

HCID 7503Benzyl ChlorideHCID 14798Sodium HydroxideHCID 1785092965-amino-1H-1,2,4-triazole-3-thiol

생성물 1

HCID 7372725-(benzylsulfanyl)-4H-1,2,4-triazol-3-amine수율 90.6%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

3-Amino-5-mercapto-1,2,4-triazole (40.36 g) was treated at room temperature with sodium hydroxide (13.9 g) in ethanol (450 ml), and benzyl chloride (44.3 g) was added. The mixture was stirred overnight, and was then filtered. The ethanol was evaporated off, and the residue was recrystallised from ethyl acetate to give 64.97 g of the desired product, mp 104° C.

후처리

  1. additionwas added
  2. filtrationwas then filtered
  3. customThe ethanol was evaporated off
  4. customthe residue was recrystallised from ethyl acetate

출처 및 근거

ORD 기록
ord-b82cfc36a6374223bdd0d890c06b2c86
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889553

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