Hydrochloric Acid → 2-Fluoro-5-iodobenzoic acid

HRID 477869

반응식

HRID 477869 반응식
[K].[F:2][C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][C:4]=1[CH3:10].S(=O)(=O)(O)[O-:12].[Na+].Cl.[OH2:18]>C(Cl)Cl>[F:2][C:3]1[CH:8]=[CH:7][C:6]([I:9])=[CH:5][C:4]=1[C:10]([OH:12])=[O:18]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 962WaterHCID 516919Sodium BisulfateHCID 5211782-Fluoro-5-iodotolueneHCID 5462222Potassium

생성물 1

HCID 27789252-Fluoro-5-iodobenzoic acid수율 15%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 8.1 g (51.3 mmol) of potassium permangante in 150 mL of water are added 5.0 g (21.1 mmol) of 2-fluoro-5-iodotoluene. The reaction mixture is heated at reflux for 4 hours. After being cooled to room temperature, the reaction mixture is poured into 250 mL of methylene chloride of sodium bisulfate, and 1N hydrochloric acid. The organic layer is separated, washed with water and dried over sodium sulfate. The solvent is removed in vacuo and the solid triturated with hexane to give 0.86 g (15%) of 2-fluoro-5-iodobenzoic acid as a white solid, m.p. 161°-163° C.

후처리

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for 4 hours
  3. customThe organic layer is separated
  4. washwashed with water
  5. dry with materialdried over sodium sulfate
  6. customThe solvent is removed in vacuo
  7. customthe solid triturated with hexane

출처 및 근거

ORD 기록
ord-38325e46048d45498f4cbe61cff342e0
출처 데이터셋
uspto-grants-1989_12
특허 번호
US04889859

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