Ethanol → HCID 3045156, 화합물

HRID 480422노트

반응식

HRID 480422 반응식
[CH3:1][C:2]([CH3:7])([CH3:6])[C:3](=[O:5])[CH3:4].[N:8]1[CH:13]=[CH:12][C:11]([CH:14]=O)=[CH:10][CH:9]=1.C(O)C.[OH-].[Na+]>ClCCl>[C:2]([C:3](=[O:5])[CH:4]=[CH:14][C:11]1[CH:12]=[CH:13][N:8]=[CH:9][CH:10]=1)([CH3:7])([CH3:6])[CH3:1]

참가 물질

6

반응물 4

HCID 702EthanolHCID 6416PinacoloneHCID 133894-PyridinecarboxaldehydeHCID 14798Sodium Hydroxide

생성물 1

HCID 3045156HCID 3045156, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 3,3-dimethyl-2-butanone (2.5 ml, 20.0 mmol), 4-pyridinecarboxaldehyde (2.15 ml, 22.3 mmol), ethanol (7.6 ml), and 4.5% aqueous sodium hydroxide (4.6 ml) was kept at room temperature for 12 h. It was diluted with dichloromethane, washed with aqueous hydrochloric acid and water, dried and evaporated. Subsequent column chromatography (hexane-ethyl acetate=3:1) provided the title compound. MS (m/z): 190.4 (M+H)+; C12H15NO requir. 189.3.

후처리

  1. washwashed with aqueous hydrochloric acid and water
  2. customdried
  3. customevaporated

출처 및 근거

ORD 기록
ord-36b04c5defaf4828b8bfba1948e3b238
출처 데이터셋
uspto-grants-2003_11
특허 번호
US06649604B2

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