Water → 4-(1,1-Dicyanoethyl)anisole

HRID 481509

반응식

HRID 481509 반응식
[C:1]([CH:3]([C:12]#[N:13])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][CH:5]=1)#[N:2].[H-].[Na+].[CH3:16]I.O>CN(C=O)C>[C:1]([C:3]([C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[CH:6][CH:5]=1)([C:12]#[N:13])[CH3:16])#[N:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 641441(4-Methoxyphenyl)malononitrile

생성물 1

HCID 190664454-(1,1-Dicyanoethyl)anisole수율 268.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a mixture of Compound 35 (1.0 g, 6.0 mmol) and NaH (280 mg, 7.0 mmol) in DMF (12 ml) was added MeI (1.0 g, 7.0 mmol) at room temperature. After the mixture was stirred for 22 hours, the mixture was poured into H2O (30 ml), and extracted with CH2Cl2. The combined extracts were dried (Na2SO4), and concentrated to give a yellow oil (3 g), which was purified by a column chromatography on silica gel to give Compound 35 as a colorless solid (900 mg, 81%).

후처리

  1. extractionextracted with CH2Cl2
  2. dry with materialThe combined extracts were dried (Na2SO4)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1f92e4c444b74b1aa93def5842cf23b9
출처 데이터셋
uspto-grants-1998_08
특허 번호
US05789423

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