Hydrochloric Acid → 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid cyclohexylamide

HRID 491894노트

반응식

HRID 491894 반응식
[CH2:1]([N:8]1[CH:12]=[N:11][C:10]([C:13]([OH:15])=O)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:16]1([NH2:22])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1.C(N(CC)C(C)C)(C)C.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.Cl>CN(C=O)C>[CH:16]1([NH:22][C:13]([C:10]2[N:11]=[CH:12][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[N:9]=2)=[O:15])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 7965CyclohexylamineHCID 81531DiisopropylethylamineHCID 2733084Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 157079191-Benzyl-1H-1,2,4-triazole-3-carboxylic acid

생성물 1

HCID 670235851-benzyl-1H-[1,2,4]triazole-3-carboxylic acid cyclohexylamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a stirred solution of 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid (1.54 g, 7.6 mmol), cyclohexylamine (0.87 mL, 7.6 mmol) and N,N-diisopropylethylamine (2.65 mL, 15.1 mmol) in DMF (30 mL) was added HBTU (3.45 g, 9.1 mmol). The solution was then stirred at room temperature overnight. Aqueous hydrochloric acid was added and the solution was filtered to yield 1-benzyl-1H-[1,2,4]triazole-3-carboxylic acid cyclohexylamide as a white solid.

후처리

  1. filtrationthe solution was filtered

출처 및 근거

ORD 기록
ord-aa2e6891a99c492dafa40db9546ccacb
출처 데이터셋
uspto-grants-2009_05
특허 번호
US07531545B2

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