Benzylamine → HCID 178418897, 화합물

HRID 496853

반응식

HRID 496853 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)S(O[Si](C)(C)C)(=O)=O.[OH-].[Na+].[CH2:23]([S:25][C:26]#[N:27])[CH3:24]>>[CH2:1]([NH:8][C:26](=[NH:27])[S:25][CH2:23][CH3:24])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 4

HCID 7504BenzylamineHCID 10968Ethyl thiocyanateHCID 14798Sodium HydroxideHCID 65367Trimethylsilyl triflate

생성물 1

HCID 178418897HCID 178418897, 화합물수율 100%

실험 절차

Benzylamine (13.8 mg) was dissolved in ethyl thiocyanate (50 μl). To this solution, trimethylsilyl trifluoromethanesulfonate (25.7 μl) was added dropwise at room temperature. After continued stirring for 1 day at room temperature, 2N aqueous sodium hydroxide was added to the solution, which was then extracted with ethyl acetate. The ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the titled compound (25.4 mg, yield 100%).

후처리

  1. extractionwas then extracted with ethyl acetate
  2. dry with materialThe ethyl acetate layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-49041b3ebb874c15837593d62ea1d631
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06946576B2

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