Hydrochloric Acid → N-(2-fluorophenyl)-2-(hydroxyimino)acetamide

HRID 497986

반응식

HRID 497986 반응식
Cl[C:2](Cl)(Cl)[CH:3]([OH:5])O.S([O-])([O-])(=O)=O.[Na+].[Na+].[F:15][C:16]1[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=1[NH2:18].Cl.Cl.[NH2:25][OH:26]>O>[F:15][C:16]1[CH:22]=[CH:21][CH:20]=[CH:19][C:17]=1[NH:18][C:3](=[O:5])[CH:2]=[N:25][OH:26]

참가 물질

7

반응물 5

HCID 313Hydrochloric AcidHCID 2707Chloral HydrateHCID 95842-FluoroanilineHCID 24436Sodium SulfateHCID 443297Hydroxyamine hydrochloride

생성물 1

HCID 6710880N-(2-fluorophenyl)-2-(hydroxyimino)acetamide수율 86%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

The title compound was prepared according to the method described in J. Heterocyclic Chem., vol. 27, p. 2151 (1990). To a solution of chloral hydrate (44.2 g, 267 mmol) and sodium sulfate (304 g, 2.14 mol) in water (700 mL), was added a solution of 2-fluoroaniline (27.0 g, 243 mmol) and conc. hydrochloric acid (70 mL) in water (140 mL) dropwise at room temperature, and furthermore hydroxylamine hydrochloride (74.4 g, 1.07 mol), and the resulting solution was heated under reflux for 10 minutes. The solution was ice cooled and the resulting crystals were collected by filtration and air dried to give the title compound (38.0 g, 86% yield).

후처리

  1. customThe title compound was prepared
  2. temperatureunder reflux for 10 minutes
  3. temperaturecooled
  4. filtrationthe resulting crystals were collected by filtration and air
  5. customdried

출처 및 근거

ORD 기록
ord-bc77d98539d54525af175b434f6f2e5a
출처 데이터셋
uspto-grants-2005_09
특허 번호
US06949648B2

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