Hydrochloric Acid → 2-Nitro-4-trifluoromethoxy-benzenesulfonyl chloride

HRID 513373

반응식

HRID 513373 반응식
[O:1]=[S:2]([Cl:4])Cl.[N+:5]([C:8]1[CH:14]=[C:13]([O:15][C:16]([F:19])([F:18])[F:17])[CH:12]=[CH:11][C:9]=1N)([O-:7])=[O:6].Cl.N([O-])=[O:22].[Na+]>O.Cl[Cu]>[N+:5]([C:8]1[CH:14]=[C:13]([O:15][C:16]([F:19])([F:18])[F:17])[CH:12]=[CH:11][C:9]=1[S:2]([Cl:4])(=[O:1])=[O:22])([O-:7])=[O:6]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 27757722-Nitro-4-(trifluoromethoxy)anilineHCID 23668193Sodium Nitrite

생성물 1

HCID 866697542-Nitro-4-trifluoromethoxy-benzenesulfonyl chloride수율 105.4%

시약·촉매·용매 2

HCID 62652Cuprous chloride촉매HCID 962Water용매2회

실험 절차

In a similar fashion using route 3a general procedure 10, SOCl2 (0.36 ml, 4.95 mmol) in cold water (2 ml), CuCl (5 mg, 0.05 mmol), 2-nitro-4-(trifluoromethoxy)aniline (200 mg, 0.90 mmol), conc. HCl (2 ml), NaNO2 (90 mg, 1.3 mmol) in water (2 ml) gave the title compound (290 mg) which was used in the next step without further purification. The structure was confirmed by 1H NMR.

출처 및 근거

ORD 기록
ord-1e0fd975f5f94606babf2e5cfa5654ae
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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