Benzenesulfonyl chloride → N-(7-Chloro-quinolin-8-yl)-benzenesulfonamide

HRID 513480

반응식

HRID 513480 반응식
[Cl:1][C:2]1[C:11]([NH2:12])=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:13]1([S:19](Cl)(=[O:21])=[O:20])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CN(C1C=CN=CC=1)C.CCCCC>[Cl:1][C:2]1[C:11]([NH:12][S:19]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)(=[O:21])=[O:20])=[C:10]2[C:5]([CH:6]=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 7369Benzenesulfonyl chlorideHCID 2247847-Chloroquinolin-8-amine2회

생성물 1

HCID 60164005N-(7-Chloro-quinolin-8-yl)-benzenesulfonamide수율 61.6%

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 8003Pentane용매

실험 절차

In a similar fashion using route 14 general procedure 27, 7-chloroquinolin-8-amine (Intermediate 52) (100 mg, 0.56 mmol), benzenesulfonyl chloride (110 mg, 0.67 mmol) and DMAP (cat.) gave the title compound (110 mg, 56%) after trituration from n-pentane.

출처 및 근거

ORD 기록
ord-35b5932c20fd43a2b738a1ac2df0dfee
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09102688B2

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