Hydrochloric Acid → HCID 178479550, 화합물

HRID 514681

반응식

HRID 514681 반응식
[NH2:1][CH:2]([C:6]([NH2:8])=[O:7])[C:3]([NH2:5])=[O:4].[C:9](O)(=O)C(O)=[O:11].C(OCC)(OCC)OCC.[ClH:25]>O.CC(O)C>[OH2:4].[OH2:11].[ClH:25].[OH:4][C:3]1[NH:5][CH:9]=[N:1][C:2]=1[C:6]([NH2:8])=[O:7]

참가 물질

7

반응물 4

HCID 313Hydrochloric AcidHCID 971Oxalic AcidHCID 31214Ethyl orthoformateHCID 964572-Aminopropanediamide

생성물 1

HCID 178479550HCID 178479550, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 3776Isopropanol용매

반응 조건

온도
82 °C

실험 절차

Under the nitrogen atmosphere, 30 g of 2-aminomalonamide and 115 mg of oxalic acid were added to 600 mL of 2-propanol. After heating to 82° C., 106 mL of triethyl orthoformate was added dropwise to the mixture over 10 minutes. Subsequently, the reaction mixture was stirred for 7 hours and 30 minutes at 84° C. Subsequently, after cooling to 57° C., the reaction mixture was added with 30 mL of water followed by 24 mL of conc. hydrochloric acid. After cooling the reaction mixture to 5° C., the crystal was collected by filtration and then washed with 120 mL of acetone to give 49 g of 5-hydroxy-1H-imidazole-4-carboxamide hydrochloric acid salt dihydrate as a pale yellow crystal.

후처리

  1. temperatureSubsequently, after cooling to 57° C.
  2. temperatureAfter cooling the reaction mixture to 5° C.
  3. filtrationthe crystal was collected by filtration
  4. washwashed with 120 mL of acetone

출처 및 근거

ORD 기록
ord-a8a07c408937410580ad2da2a964a2b6
출처 데이터셋
uspto-grants-2015_08
특허 번호
US09108928B2

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