Acetic Anhydride → Diisopropylethylamine

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[C:1](OC(=O)C)(=O)C.C(O[C:13](=O)[CH2:14][CH3:15])(=O)CC.C([N:19]([CH2:22][CH3:23])[CH2:20][CH3:21])C.C1COCC1>C(OC(=O)C)C.C(COC)OC.C1(C)C=CC=CC=1>[CH:22]([N:19]([CH:14]([CH3:13])[CH3:15])[CH2:20][CH3:21])([CH3:23])[CH3:1]

참가 물질

실험 절차

The amide acid VIIC is cyclized by treatment with a cyclizing agent such as acetic anhydride or propionic anhydride (employing a molar ratio of anhydride:VIIC of within the range of from about 7:1 to about 5:1) and amine base such as triethylamine or diisopropylethylamine, in the presence of an inert organic solvent such as THF, toluene, monoglyme or ethylacetate, at a temperature within the range of from about 70° to about 110° C., to form compound XXVIII.

출처 및 근거

ORD 기록: ord-6d4ad5631c0b48418e89b9ef8300b1c7
출처 데이터셋: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05618946

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참가 물질

반응물 4

HCID 7918Acetic Anhydride

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 31263Propionic anhydride

생성물 1

HCID 81531Diisopropylethylamine

시약·촉매·용매 3

HCID 1140Toluene용매

HCID 80711,2-Dimethoxyethane용매