Hydrochloric Acid → 6-Methyl-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxylic acid

HRID 543041

반응식

HRID 543041 반응식
N[C:2]1C=CC=CC=1.Cl.N([O-])=O.[Na+].[Cl-].[C:14]1([N+:20]#[N:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[O:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]1=[O:28].[OH-:29].[Na+]>O>[C:14]1([N:20]2[C:27]([CH3:2])=[CH:26][C:25](=[O:29])[C:24]([C:23]([OH:22])=[O:28])=[N:21]2)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

8

반응물 6

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 14798Sodium HydroxideHCID 60992Benzenediazonium chlorideHCID 681542H-Pyran-2-oneHCID 23668193Sodium Nitrite

생성물 1

HCID 27844706-Methyl-4-oxo-1-phenyl-1,4-dihydropyridazine-3-carboxylic acid

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

In a separate flask; 9.08 g of aniline is mixed with 37.5 ml of concentrated hydrochloric acid and 47 ml of water. The resulting solution is maintained at about 5° to 10° and a solution of 7.13 g of sodium nitrite in 24 ml of water is added. The resulting solution of phenyldiazonium chloride is added dropwise to the stirred pyrone solution, while maintaining a temperature of about 5° to 10°. The pH is maintained at about 8 to 9 by the addition of small amounts of sodium hydroxide solution.

후처리

  1. temperatureThe resulting solution is maintained at about 5° to 10°
  2. temperaturewhile maintaining a temperature of about 5° to 10°

출처 및 근거

ORD 기록
ord-3ab5e60f47054849a6871ffbb2463730
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04661145

연결된 노트

불러오는 중…