Phosphorus oxychloride → HCID 20460009, 화합물

HRID 544268

반응식

HRID 544268 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:16][CH2:17][C:18]#[N:19])[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=O)[CH:6]=[CH:7][CH:8]=1.[BH4-].[Na+].COC1C=C(C2(CCC#N)CCCCC2O)C=CC=1.P(Cl)(Cl)(Cl)=O.COC1C=C(C2(CC#N)CCCC=C2)C=CC=1>N1C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]2([CH2:16][CH2:17][C:18]#[N:19])[CH2:14][CH2:13][CH2:12][CH:11]=[CH:10]2)[CH:6]=[CH:7][CH:8]=1

참가 물질

7

반응물 5

HCID 24813Phosphorus oxychlorideHCID 4311764Sodium borohydrideHCID 12838393HCID 12838393, 화합물HCID 204600021-(m-Methoxyphenyl)-2-hydroxycyclohexane-1-propionitrileHCID 204600081-(m-Methoxyphenyl)-2-oxo-cyclohexane-propionitrile

생성물 1

HCID 20460009HCID 20460009, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

By reducing 1-(m-methoxyphenyl)-2-oxo-cyclohexane-propionitrile with sodium borohydride and subsequently dehydrating the resulting 1-(m-methoxyphenyl)-2-hydroxycyclohexane-1-propionitrile with phosphorus oxychloride in pyridine in analogy to the preparation of 1-(m-methoxyphenyl)-2-cyclohexene-1-acetonitrile described in Example 1, there is obtained 1-(m-methoxyphenyl)-2-cyclohexene-1-propionitrile in the form of a pale yellowish oil.

출처 및 근거

ORD 기록
ord-626384479d06429d913706bb25191e53
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04448991

연결된 노트

불러오는 중…