Hydrochloric Acid → (4-Hydroxyphenoxy)acetic acid

HRID 546360

반응식

HRID 546360 반응식
C[O:2][C:3](=[O:13])[CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.Cl>[OH-].[Na+]>[OH:12][C:9]1[CH:8]=[CH:7][C:6]([O:5][CH2:4][C:3]([OH:13])=[O:2])=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 602731Methyl 2-(4-hydroxyphenoxy)acetate

생성물 1

HCID 15881(4-Hydroxyphenoxy)acetic acid

시약·촉매·용매 1

HCID 14798Sodium Hydroxide용매

반응 조건

온도
90 °C

실험 절차

(4-Hydroxy-phenoxy)-acetic acid methyl ester 11 (20 grams, 109.89 mmol) is added to 10% sodium hydroxide solution (100 mL) and heated to 90° C. on water bath for 6 hours. The reaction mixture is cooled to room temperature, and the pH is adjusted to 2 with distilled HCl. Crude 12, is filtered, dried, and can be recrystallised in appropriate solvent.

후처리

  1. temperatureThe reaction mixture is cooled to room temperature
  2. filtrationCrude 12, is filtered
  3. customdried
  4. customcan be recrystallised in appropriate solvent

출처 및 근거

ORD 기록
ord-9b60dbd7e8564d3083558297cd3660ca
출처 데이터셋
uspto-grants-2011_05
특허 번호
US07935843B2

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