Methyl iodide → Methyl N-methylindole-6-carboxylate

HRID 564968

반응식

HRID 564968 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1.[OH-].[Na+].[CH3:16]I>CN(C)C=O>[CH3:16][N:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:10]([O:12][CH3:13])=[O:11])[CH:8]=2)[CH:3]=[CH:2]1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 14798Sodium HydroxideHCID 639844Methyl indole-6-carboxylate

생성물 1

HCID 639843Methyl N-methylindole-6-carboxylate수율 86.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The reaction was carried out in a manner similar to Reference Example 4 except for using 3.00 (17.1 mmol) of methyl 6-indolecarboxylate, 0.68 g (17.1 mmol) of 60% sodium hydroxide, 4.86 g (34.4 mmol) of methyl iodide and 60 ml of dimethylformamide. Thus 2.75 g (86.9%) of methyl 1-methyl-6-indolecarboxylate was obtained.

출처 및 근거

ORD 기록
ord-f255b6cf83d24db78da4f92e4e6da3fc
출처 데이터셋
uspto-grants-2001_01
특허 번호
US06169107A

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