반응식
[Br:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.[CH:9]1([CH2:12][CH:13](OS(C)(=O)=O)[C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:11][CH2:10]1.[H-].[Na+].[Br-].[Li+]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH:13]([CH2:12][CH:9]2[CH2:11][CH2:10]2)[C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:4](=[O:8])[CH:3]=1참가 물질
5
반응 조건
- 온도
- 65 °C
실험 절차
1.02 g (5.87 mmol) of 4-bromopyridin-2(1H)-one and 2.23 g (purity 56%, 5.28 mmol) of ethyl 3-cyclopropyl-2-[(methylsulphonyl)oxy]propanoate (racemate) in the presence of 1.15 eq. of sodium hydride and 2.3 eq. of lithium bromide were reacted according to General Method 4C (stirred at 65° C. overnight). Yield: 246 mg (13% of theory)
출처 및 근거
- ORD 기록
- ord-e4b0243d8a54422bb0021d2b39bd193f
- 출처 데이터셋
- uspto-grants-2016_09
- 특허 번호
- US09434690B2
연결된 노트
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