Methyl iodide → 6-Methoxythieno[3,2-b]pyridine

HRID 569072노트

반응식

HRID 569072 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.[H-].[Na+].[CH3:13]I>CS(C)=O>[CH3:13][O:1][C:2]1[CH:3]=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 20148567Thieno[3,2-b]pyridin-6-ol

생성물 1

HCID 201485826-Methoxythieno[3,2-b]pyridine수율 78.5%

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

To a solution of 6-hydroxythieno[3,2-b]pyridine (2.45 g, 16.2 mmol) in dry dimethylsulfoxide (15 ml), under a nitrogen atmosphere, was added 60% sodium hydride in mineral oil (0.75 g, 19 mmol) and let stir at room temperature for 1 hour. Methyl iodide (1.25 ml, 21 mmol) was added to this solution and it was stirred for an additional two hours. The solution was poured into ice/water and extracted with diethyl ether, washed with water, dried over anhydrous sodium sulfate, filtered and carefully evaporated to give an oily product (2.1 g, 78% yield) which was used as is.

후처리

  1. stirringwas stirred for an additional two hours
  2. extractionextracted with diethyl ether
  3. washwashed with water
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. customcarefully evaporated

출처 및 근거

ORD 기록
ord-5e4ad5e54b854f339997a2ef5d46f549
출처 데이터셋
uspto-grants-1988_03
특허 번호
US04731368

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