Benzaldehyde → 2-(Benzylamino)-2-methylpropane-1,3-diol

HRID 584227

반응식

HRID 584227 반응식
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:9][C:10]([CH3:15])([CH2:13][OH:14])[CH2:11][OH:12].[BH4-].[Na+].[OH-].[Na+]>CO.C(OCC)(=O)C>[CH2:1]([NH:9][C:10]([CH3:15])([CH2:13][OH:14])[CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 240BenzaldehydeHCID 15312-Amino-2-methyl-1,3-propanediolHCID 14798Sodium HydroxideHCID 4311764Sodium borohydride

생성물 1

HCID 1987392-(Benzylamino)-2-methylpropane-1,3-diol

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

Benzaldehyde (17.4 ml) was added dropwise to a solution of 2-amino-2-methyl-1,3-propanediol (20 g) in methanol (200 ml) at 0° C. and the whole was stirred at room temperature for 2 hours. Sodium borohydride (11.5 g) was added thereto in portions at 0° C. and the mixture was stirred for 10 minutes. 1N Sodium hydroxide solution and ethyl acetate were added and the organic layer was separated, dried over magnesium sulfate, and evaporated in vacuo to give 2-benzylamino-2-methyl-1,3-propanediol (28.54 g).

후처리

  1. stirringin portions at 0° C. and the mixture was stirred for 10 minutes
  2. customthe organic layer was separated
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-d6eaeaec6c984751a5cd14c9cb938246
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06924278B2

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