1-(2-Hydroxyethyl)piperazine → 1-Acetyl-4-(2-hydroxyethyl)piperazine

HRID 586406

반응식

HRID 586406 반응식
[OH:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>C1(C)C=CC=CC=1>[C:10]([N:7]1[CH2:8][CH2:9][N:4]([CH2:3][CH2:2][OH:1])[CH2:5][CH2:6]1)(=[O:12])[CH3:11]

참가 물질

4

반응물 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 7918Acetic Anhydride

생성물 1

HCID 47396291-Acetyl-4-(2-hydroxyethyl)piperazine

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
80 °C

실험 절차

To a solution of 1-(2-hydroxyethyl)piperazine (5.5 ml; 42.3 mmol) in toluene (50 ml) was added acetic anhydride (4.0 ml; 42.4 mmol). The mixture was heated to 80° C. overnight. The solvent was removed under reduced pressure and the residue was washed several times with a mixture of diethyl ether and petroleum ether (1:1 v/v) to leave 6q1 as an oil (5.2 g; 72%).

후처리

  1. customThe solvent was removed under reduced pressure
  2. washthe residue was washed several times
  3. additionwith a mixture of diethyl ether and petroleum ether (1:1 v/v)
  4. customto leave 6q1 as an oil (5.2 g; 72%)

출처 및 근거

ORD 기록
ord-42f75320e462433eba0a700c6284fe01
출처 데이터셋
uspto-grants-2005_08
특허 번호
US06936613B2

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