Sodium Hydroxide → (7-Chloro-6-hydroxy-1-benzofuran-3-yl)acetic acid

HRID 591464

반응식

HRID 591464 반응식
[OH-:1].[Na+].[Cl:3][C:4]1[C:5]([OH:17])=[CH:6][CH:7]=[C:8]2[C:13]=1[O:12][C:11](=[O:14])[CH:10]=[C:9]2[CH2:15]Cl>Cl>[Cl:3][C:4]1[C:13]2[O:12][CH:15]=[C:9]([CH2:10][C:11]([OH:14])=[O:1])[C:8]=2[CH:7]=[CH:6][C:5]=1[OH:17]

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 897679298-Chloro-4-(chloromethyl)-7-hydroxy-2H-chromen-2-one

생성물 1

HCID 89767735(7-Chloro-6-hydroxy-1-benzofuran-3-yl)acetic acid

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

반응 조건

온도
100 °C

실험 절차

A mixture of 1N NaOH (56.7 mL) and 8-chloro-4-(chloromethyl)-7-hydroxy-2H-chromen-2-one (2.78 g) was stirred at 100° C. for 1 h. After cooling, the reaction mixture was acidified with 6N HCl (10 mL). The precipitate was collected by filtration to give the title compound (1.65 g).

후처리

  1. temperatureAfter cooling
  2. filtrationThe precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-9cb8e4a309144364acb0d39132346473
출처 데이터셋
uspto-grants-2016_01
특허 번호
US09238639B2

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