Chloroacetamide → 2-(3-Aminophenoxy)acetamide

HRID 596600노트

반응식

HRID 596600 반응식
[H-].[Na+].[OH:3][C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7].Cl[CH2:12][C:13]([NH2:15])=[O:14]>O>[NH2:7][C:6]1[CH:5]=[C:4]([CH:10]=[CH:9][CH:8]=1)[O:3][CH2:12][C:13]([NH2:15])=[O:14]

참가 물질

5

반응물 3

HCID 6580ChloroacetamideHCID 115683-AminophenolHCID 24758Sodium hydride2회

생성물 1

HCID 104872522-(3-Aminophenoxy)acetamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 50% sodium hydride (5.76 g., 0.12 M), 3-hydroxyaniline (13.09 g., 0.12 M) and chloroacetamide (11.22 g., 0.12 M) is stirred at room temperature for 18 hours. The mixture is diluted with water to decompose residual sodium hydride and is then extracted with chloroform. The chloroform extract is dried (MgSO4) and concentrated to an oil under reduced pressure. The addition of chloroform causes it to crystallize. Yield = 10.0g. (50%); m.p. 107°-111° C.

후처리

  1. extractionis then extracted with chloroform
  2. extractionThe chloroform extract
  3. dry with materialis dried (MgSO4)
  4. concentrationconcentrated to an oil under reduced pressure
  5. additionThe addition of chloroform
  6. customto crystallize

출처 및 근거

ORD 기록
ord-2da4fd088a824536b4dbb61669342ccb
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04011324

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