3-Chloropropionitrile → 3-(3-Trifluoromethylphenylthio)-propionitrile

HRID 597392

반응식

HRID 597392 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[C:5]([SH:9])[CH:6]=[CH:7][CH:8]=1.[OH-].[Na+].Cl[CH2:15][CH2:16][C:17]#[N:18]>O>[F:11][C:2]([F:1])([F:10])[C:3]1[CH:4]=[C:5]([S:9][CH2:15][CH2:16][C:17]#[N:18])[CH:6]=[CH:7][CH:8]=1

참가 물질

5

반응물 3

HCID 109633-ChloropropionitrileHCID 14798Sodium HydroxideHCID 1367513-(Trifluoromethyl)benzenethiol

생성물 1

HCID 198439363-(3-Trifluoromethylphenylthio)-propionitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 15.9 g (0.09 mol) of 3-trifluoromethylthiophenol and 3.8 g (0.095 mol) of sodium hydroxide pellets in 100 ml of water is heated at 65°-70° C and 8.5 g (0.095 mol) of β-chloropropionitrile are added dropwise whilst stirring. The mixture is heated for a quarter of an hour to the reflux temperature and is then cooled and extracted with ether, and the extract is washed with water and dried with magnesium sulphate. This gives 3-(3-trifluoromethylphenylthio)-propionitrile, which is not isolated.

후처리

  1. temperatureThe mixture is heated for a quarter of an hour to the reflux temperature
  2. temperatureis then cooled
  3. extractionextracted with ether
  4. washthe extract is washed with water
  5. dry with materialdried with magnesium sulphate

출처 및 근거

ORD 기록
ord-56a53ea130574dc8acfa973d562739c3
출처 데이터셋
uspto-grants-1977_03
특허 번호
US04013776

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