2-Phenyl-1-propanol → 2-(2-Phenylpropoxy)acetic acid

HRID 613754

반응식

HRID 613754 반응식
[C:1]1([CH:7]([CH3:10])[CH2:8][OH:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O:15][C:16](=[O:19])[CH2:17]Br)(C)(C)C.[OH-].[Na+]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[C:1]1([CH:7]([CH3:10])[CH2:8][O:9][CH2:17][C:16]([OH:19])=[O:15])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

6

반응물 3

HCID 142952-Phenyl-1-propanolHCID 14798Sodium HydroxideHCID 79177tert-Butyl bromoacetate

생성물 1

HCID 187790482-(2-Phenylpropoxy)acetic acid수율 77.1%

시약·촉매·용매 2

HCID 74236Tetrabutylammonium Bromide촉매HCID 1140Toluene용매

실험 절차

The subtitle compound (14.95 g) was prepared according to the procedure in example 6 part a using 2-phenyl-1-propanol (13.6 g), t-butylbromoacetate (19.5 g), tetrabutylammoniumbromide (3.2 g), toluene (70 ml), 50% aqueous sodium hydroxide (25 ml).

출처 및 근거

ORD 기록
ord-1dc0d09ba33d4def9ac4e2c4d6dd760b
출처 데이터셋
uspto-grants-1999_12
특허 번호
US06008365

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