Pyridine → 5-Methoxy-2-(3-nitrobenzoyl)aminobenzamide

HRID 61630

반응식

HRID 61630 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].N1C=CC=CC=1.[N+:19]([C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25](Cl)=[O:26])([O-:21])=[O:20]>C(Cl)(Cl)Cl>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:2]([NH:1][C:25](=[O:26])[C:24]2[CH:28]=[CH:29][CH:30]=[C:22]([N+:19]([O-:21])=[O:20])[CH:23]=2)=[C:3]([CH:7]=1)[C:4]([NH2:6])=[O:5]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 8495Benzoyl chloride, 3-nitro-HCID 203382172-Amino-5-methoxybenzamide

생성물 1

HCID 593619435-Methoxy-2-(3-nitrobenzoyl)aminobenzamide수율 133.6%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

To a suspension of 2-amino-5-methoxybenzamide (2.42 g, 14.6 mmol) and pyridine (6 mL) in CHCl3 (120 mL) was added 3-nitrobenzoyl chloride (3.0 g, 16.1 mmol). The resulting mixture was stirred at RT for 6 h. The volatiles were removed in vacuo and the resultant solid was washed with Et2O to give the 5-Methoxy-2-(3-nitrobenzoyl)aminobenzamide (6.15 g) which was taken directly on to the next step. HPLC retention time 6.58 mins.

후처리

  1. customThe volatiles were removed in vacuo
  2. washthe resultant solid was washed with Et2O

출처 및 근거

ORD 기록
ord-fc159f7e15dc4e17a0f43b00764ca618
출처 데이터셋
uspto-grants-2016_09
특허 번호
US09440961B2

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