Hydrochloric Acid → 2-Acetyl-4-methoxycyclohexanone

HRID 621710

반응식

HRID 621710 반응식
[H-].[Na+].[C:3](OCC)(=[O:5])[CH3:4].[CH3:9][O:10][CH:11]1[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH2:12]1.Cl>O.CO.C1C=CC=CC=1>[C:3]([CH:15]1[CH2:16][CH:11]([O:10][CH3:9])[CH2:12][CH2:13][C:14]1=[O:17])(=[O:5])[CH3:4]

참가 물질

8

반응물 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 24758Sodium hydride2회HCID 5350284-Methoxycyclohexanone

생성물 1

HCID 136327242-Acetyl-4-methoxycyclohexanone

시약·촉매·용매 3

HCID 241Benzene용매HCID 887Methanol용매HCID 962Water용매

실험 절차

1.12 g of 60% sodium hydride was added to 2.5 g of ethyl acetate and 1.78 g of a benzene solution of 4-methoxycyclohexanone was added thereto. After reacting at 40° C. for three hours, methanol was added to thereby decompose excessive sodium hydride and the reaction mixture was poured into water, neutralized with hydrochloric acid and extracted with ether to give 1.02 g of 2-acetyl4-methoxycyclohexanone. NMRδTMSCCl4 : 2.06 (3H, s). 1.7-2.5 (8H, s), 3.28 (3H , s), 3.4 (1H, m) and 15.9 (1H, s).

후처리

  1. additionwas added
  2. extractionextracted with ether

출처 및 근거

ORD 기록
ord-4cb7820e2c0d4756ac91ec0260e9fb9c
출처 데이터셋
uspto-grants-1989_04
특허 번호
US04824952

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