4-Fluoroaniline → 1,1-Dimethylethyl (2S)-4-({4-[({6-[(4-fluorophenyl)amino]-3-pyridinyl}carbonyl)(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

HRID 644713노트

반응식

HRID 644713 반응식
C1C=CC(P(C2C(C3C(P(C4C=CC=CC=4)C4C=CC=CC=4)=CC=C4C=3C=CC=C4)=C3C(C=CC=C3)=CC=2)C2C=CC=CC=2)=CC=1.C(=O)([O-])[O-].[Cs+].[Cs+].[F:53][C:54]1[CH:60]=[CH:59][C:57]([NH2:58])=[CH:56][CH:55]=1.Cl[C:62]1[N:67]=[CH:66][C:65]([C:68]([N:70]([CH3:92])[C:71]2[CH:76]=[CH:75][C:74]([CH2:77][N:78]3[CH2:83][CH2:82][N:81]([C:84]([O:86][C:87]([CH3:90])([CH3:89])[CH3:88])=[O:85])[C@@H:80]([CH3:91])[CH2:79]3)=[CH:73][CH:72]=2)=[O:69])=[CH:64][CH:63]=1>O1CCOCC1.C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[F:53][C:54]1[CH:60]=[CH:59][C:57]([NH:58][C:62]2[N:67]=[CH:66][C:65]([C:68]([N:70]([CH3:92])[C:71]3[CH:76]=[CH:75][C:74]([CH2:77][N:78]4[CH2:83][CH2:82][N:81]([C:84]([O:86][C:87]([CH3:89])([CH3:88])[CH3:90])=[O:85])[C@@H:80]([CH3:91])[CH2:79]4)=[CH:73][CH:72]=3)=[O:69])=[CH:64][CH:63]=2)=[CH:56][CH:55]=1

참가 물질

7

반응물 4

HCID 97314-FluoroanilineHCID 10796Cesium carbonateHCID 634876Binap, (A+-)-HCID 592622291,1-Dimethylethyl (2S)-4-({4-[[(6-chloro-3-pyridinyl)carbonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate

생성물 1

HCID 592622221,1-Dimethylethyl (2S)-4-({4-[({6-[(4-fluorophenyl)amino]-3-pyridinyl}carbonyl)(methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate수율 47.3%

시약·촉매·용매 2

HCID 167845palladium(II) acetate촉매HCID 312751,4-Dioxane용매

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온도
60 °C

실험 절차

BINAP (0.041 g, 0.0654 mmol), cesium carbonate (0.213 g, 0.654 mmol) and palladium acetate (0.009 g, 0.0436 mmol) were combined in dioxane (1 mL) and sonicated for 1 h under an argon atmosphere. To the red mixture was added 4-fluoroaniline (0.053 g, 0.479 mmol) and 1,1-dimethylethyl (2S)-4-({4-[[(6-chloro-3-pyridinyl)carbonyl](methyl)amino]phenyl}methyl)-2-methyl-1-piperazinecarboxylate (D54) (0.2 g, 0.436 mmol). The mixture was stirred at 60° C. for 1 h, the solvent was removed under vacuum and the residues partitioned between EtOAc and water. The EtOAc layer was dried and concentrated. The crude product was purified by chromatography. Elution with a 0-70% EtOAc/petroleum ether gradient yielded the title compound as a pale yellow oil (0.110 g). δH (CDCl3, 400 MHz) 8.10 (1H, m), 7.40 (1H, dd), 7.25 (3H, m), 7.02 (4H, m), 6.92 (1H, s), 6.43 (1H, d), 4.18 (1H, br.s), 3.80 (1H, d), 3.48 (3H, s), 3.48 (1H, d), 3.36 (1H, d), 3.10 (1H, td), 2.70 (1H, d), 2.52 (1H, d), 2.10 (1H, m), 1.98 (1H, m), 1.85 (1H, br.s), 1.45 (9H, s), 1.20 (3H, d). MS (ES): MH+ 534.3.

후처리

  1. customsonicated for 1 h under an argon atmosphere
  2. customthe solvent was removed under vacuum
  3. customthe residues partitioned between EtOAc and water
  4. dry with materialThe EtOAc layer was dried
  5. concentrationconcentrated
  6. customThe crude product was purified by chromatography
  7. washElution with a 0-70% EtOAc/petroleum ether gradient

출처 및 근거

ORD 기록
ord-3db0071f262e47b99c7ea64f47ddb092
출처 데이터셋
uspto-grants-2010_04
특허 번호
US07700599B2

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